Endocrine Abstracts

Introduction: Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease. Patients affected by NF1 have an increased risk of developing tumors other than neurofibromas, especially of endocrine origin, that’s why this patients should be screened for endocrine lesions. In this report, we describe a patient affected by NF1 who present a thyroid nodule.Observation: A 27-year-old woman was admitted in our department for endocrinological evaluati...

Introduction: Acromegaly is the set of clinical manifestations induced by chronic exposure to an endogenous excess of growth hormone (GH). Most often, acromegaly is related to GH production by a pituitary adenoma. It may be associated with neuroendocrine tumors of the pancreas as part of multiple endocrine neoplasia type 1 (MEN1). Herein, we described a tumor mimicking a carcinoma of the Ampulla of Vater in a patient with acromegaly.Observation: A 54-yea...

Introduction: It has been generally accepted that adrenal function might be impaired in patients with primary hypothyroidism. A transitory low glucocorticoid production has been identified in cases with severe hypothyroidism. We tried to evaluate adrenocortical glucocorticoid function using the low-dose Synacthen test, in patients with primary hypothyroidism. The primary endpoint was to contrast the cortisol response to low-dose Synacthen before L-T4 replacement and after norm...

Grave’s disease (GD), like all autoimmune diseases, is predominantly female, with sex ratio to 3 women for one man. The treatment of first intension is based on antithyroid drugs (ATD). Our objective is to compare the clinical presentation and the evolution of GD by gender. It’s a retrospective study. We studied patients with a first diagnosis of GD, in the department of endocrinology in Farhat Hached hospital in Susah, between Juanuary 2010 and December 2015. The pa...

Introduction: Diabetic foot is known to represent a serious complication of diabetes mellitus, responsible for significant morbidity, disability and considerable financial implications. The prevention of this complication requires, first and foremost, a good patient education.Objective: To evaluate the current state of knowledge and practices of foot care in diabetic patients and to identify factors associated with a good educational level.<p class="...

Introduction: Contrary to type 2 diabetes, type 1 often occurs in young people, without obesity or cardiovascular or metabolic diseases. The association of type 1 diabetes with an authentic metabolic syndrome including obesity is very rare, though possible, with a mixed clinical picture. The goal of our study is to evaluate the association of type 1 diabetes with the metabolic syndrome.Material and methods: This is a retrospective cross-sectional study b...

Introduction: Type 1 Diabetes is an auto-immune disease caused by a disturbance of the immune system, damaging the Beta-cells. The association with other auto-immune diseases was frequently described, and dysthyroidism represents an important part of these associations. In type 1 diabetes, the hormonal profile can be disturbed regardless of auto-immunity. The goal of our study the thyroid hormonal profile in type 1 diabetes, as well as the prevalence of auto-immune dysthyroidi...

In ACTH-independent macronodular adrenal hyperplasia (AIMAH) causing Cushing’s syndrome, cortisol secretion is controlled by illegitimate membrane receptors. In the normal adrenal gland, agonists of 5-HT4 receptors have a powerful effect on aldosterone secretion but little effect on cortisol secretion in vitro.The aim of our study is to describe the clinical and hormonal features of patients diagnosed with aberrant serotonin receptor expres...

Giant-cell tumor is a skeletal disorder that occurs secondarily to hyperparathyroidism and is caused by long-term stimulation of parathyroid hormone (PTH) excess. The overactivity and proliferation of osteoclasts stimulated by PTH breaks down bone and leads to replacement of bone matrix and thinning of the cortex. True giant-cell tumor is a rare jaw osteolytic benign tumor belonging to the larger family of giant-cell tumors.We report the case of a 47 yea...

Background: Gigantism indicates excessive secretion of growth hormone (GH) during childhood Pituitary gigantism is very rare and the description of the disease is limited to small series and case reports. Here, we report a case of pituitary gigantism in a child revealed with visual defect.Case report: A 14-year-old boy presented with headache and left visual loss. On examination, he had visual acuity in his right eye of 2/10. His height was 178.0 cm (3 c...